A Dose Range Finding Study to Evaluate the Efficacy and Safety of AZD9668 Administered Orally at Three Dose Levels to Patients With Chronic Obstructive Pulmonary Disease (COPD) on Treatment With Tiotropium

Completed · Phase 2 · Has a placebo group

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

The primary objective is to evaluate the dose-response relationship and efficacy of AZD9668 at 3 dose levels compared with placebo in symptomatic COPD patients by assessing effects on lung function and symptoms of COPD.

Key facts

Study ID

NCT00949975

Run by

AstraZeneca

People needed

838

Starts

2009-07-01

Expected to finish

2010-08-01

Last updated by the study team

2012-08-03

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of COPD with symptoms over 1 year
• Smokers or ex-smokers
• Males or post-menopausal females between 40 and 80 years old
• Able to use electronic devices

You may not qualify if…

• Past history or current evidence of clinically significant heart disease
• Current diagnosis of asthma
• Patients who require long term oxygen therapy
• Treatment with antibiotics within 4 weeks of study visit 1b

Where it is running

• Research Site — Valparaiso, Indiana, United States
• Research Site — Council Bluffs, Iowa, United States
• Research Site — Hickory, North Carolina, United States
• Research Site — Jefferson Hills, Pennsylvania, United States
• Research Site — Gaffney, South Carolina, United States
• Research Site — Greenville, South Carolina, United States
• Research Site — Spartanburg, South Carolina, United States
• Research Site — Boerne, Texas, United States
• Research Site — Concord, New South Wales, Australia
• Research Site — Glebe, New South Wales, Australia
• Research Site — Kogarah, New South Wales, Australia
• Research Site — Carina Heights, Queensland, Australia
• Research Site — Adelaide, South Australia, Australia
• Research Site — Daw Park, South Australia, Australia
• Research Site — Parkville, Victoria, Australia
• Research Site — Nedlands, Western Australia, Australia
• Research Site — Edmonton, Alberta, Canada
• Research Site — Vancouver, British Columbia, Canada
• Research Site — Mount Pearl, Newfoundland and Labrador, Canada
• Research Site — Antigonish Nova Scotia, Nova Scotia, Canada
• Research Site — Grimsby, Ontario, Canada
• Research Site — Hamilton, Ontario, Canada
• Research Site — Kingston, Ontario, Canada
• Research Site — Mississauga, Ontario, Canada
• Research Site — Fullerton, California, United States

Full record on ClinicalTrials.gov

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