Cytokine-Associated Depression and Social Pain
Completed · Early Phase 1
Conditions studied: Depression
In brief
Recent research has demonstrated a relationship between depression and immune system activity, specifically proinflammatory cytokine activity. Although experimentally-induced immune activation leads to increases in depressed mood, the neural correlates associated with these changes have remained largely unexplored. Based on relationships between cytokine activity, depression, and heightened physical and social pain sensitivity, I propose to investigate the effect of proinflammatory cytokine activation on the neural correlates of socially painful experience that may contribute to depression. Our previous work has shown that the dorsal anterior cingulate cortex (dACC), typically associated with physical pain distress, also plays a role in the distressing feelings associated with social rejection or social loss. Moreover, recent pilot data has revealed that individuals with elevated levels of baseline proinflammatory cytokines report feeling more distressed and show more dACC activity during social rejection. To investigate the causal role that cytokines may play in the heightened social pain sensitivity that can contribute to depression, participants will be randomly assigned to receive either endotoxin (which increases proinflammatory cytokine activity) or placebo. Subsequently, participants will complete a neuroimaging study in which they will be rejected during an online ball-tossing game. We hypothesize that individuals exposed to endotoxin will report more social distress and depression following rejection and will show more dACC reactivity during rejection. The proposed study is the first to investigate the effect of systemic inflammation on neural reactivity related to social and affective processes that may increase the risk of depression.
Key facts
- Study ID
- NCT00949845
- Run by
- University of California, Los Angeles
- Starts
- 2007-01-01
- Last updated by the study team
- 2009-07-30
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- right-handed
You may not qualify if…
- 1) BMI greater than 30,
- 2) presence of physical health problems or medication use,
- 3) evidence of an Axis I psychiatric disorder based on the SCID assessment,
- 4) evidence of recreational drug use from a positive urine test,
- 5) positive pregnancy test, if female,
- 6) abnormalities on screening laboratory tests (blood cell count, liver function),
- 7) claustrophobia,
- 8) metal in body,
- 9) history of allergies, autoimmune, liver, or other severe chronic diseases,
- 10) current use of prescription medications,
- 11) nightshift work or time zone shifts (> 3hrs) within the previous 6 weeks.
Where it is running
- UCLA General Clinical Research Center — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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