28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years

Stopped early · Phase 4

Conditions studied: Schizophrenia

In brief

The study will assess the use of paliperidone palmitate compared with oral risperidone in delaying time to relapse in patients recently diagnosed with schizophrenia who are at high risk of relapse.

Key facts

Study ID

NCT00946985

Run by

Ortho-McNeil Janssen Scientific Affairs, LLC

People needed

163

Starts

2009-06-01

Expected to finish

2010-03-01

Last updated by the study team

2012-09-10

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must be, in the opinion of the investigator, able to understand the informed consent form approved by the Institutional Review Board (IRB) or Independent Ethics Committee (IEC), as appropriate
• All patients must sign the study informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study
• Must have a current diagnosis of schizophrenia
• must have had 3 periods of breakthrough symptoms that required a change in patient care as determined by the investigator (e.g. increase in dose, addition of a new drug, hospitalization, increase in the level of psychiatric care, notable increases in the frequency or intensity of patient contact required to maintain outpatient status, etc.) within the previous 24 months, including 1 such period within the previous 6 months
• Women must be postmenopausal, surgically sterile, or otherwise be incapable of pregnancy, abstinent, or if sexually active, be practicing a highly effective method of birth control before entry, and must agree to continue to use the same method of contraception throughout the study
• Women of childbearing potential must have a negative urine pregnancy test at screening
• Patients must be cooperative and reliable, agree to receive regular injections, and be willing/able to adhere to the prohibitions and restrictions specified in this protocol.

You may not qualify if…

• Patients who are unable to provide their own consent or are involuntarily committed to psychiatric hospitalization
• Have attempted suicide within 12 months before screening or are at imminent risk of suicide or violent behavior
• Have a positive urine drug screen test for barbiturates, cocaine, amphetamines, or opiates at screening
• Patients who are in their first episode of psychosis
• Patients currently meeting criteria for any other Axis I diagnosis except substance abuse or an Axis II diagnosis of Mental Retardation or Borderline Personality Disorder
• Meet the Diagnostic and Statistical Manual of Mental Health Disorders fourth edition (DSM-IV) definition of substance dependence (except for nicotine and caffeine dependence) within 6-months prior to entry
• Patients with known allergies, hypersensitivity (anaphylaxis-type reaction), or intolerance to paliperidone palmitate, risperidone, Risperdal®, Risperdal® Consta®, or INVEGA® or its excipients
• Patients who received Long Acting Therapy (LAT) treatment within 2 injection cycles prior to screening
• Women who are pregnant or breast-feeding, or planning to become pregnant.

Where it is running

• Study site — Garden Grove, California, United States
• Study site — San Diego, California, United States
• Study site — Washington D.C., District of Columbia, United States
• Study site — Kissimmee, Florida, United States
• Study site — Tampa, Florida, United States
• Study site — Chicago, Illinois, United States
• Study site — Hoffman Estates, Illinois, United States
• Study site — Kingsport, Indiana, United States
• Study site — Lake Charles, Louisiana, United States
• Study site — Shreveport, Louisiana, United States
• Study site — Pittsfield, Massachusetts, United States
• Study site — Minneapolis, Minnesota, United States
• Study site — Flowood, Mississippi, United States
• Study site — Creve Coeur, Missouri, United States
• Study site — St Louis, Missouri, United States
• Study site — Omaha, Nebraska, United States
• Study site — Brooklyn, New York, United States
• Study site — Middleburg Heights, Ohio, United States
• Study site — Arlington, Texas, United States
• Study site — Austin, Texas, United States
• Study site — Irving, Texas, United States
• Study site — Portsmount, Virginia, United States
• Study site — Curitiba, Brazil
• Study site — Salvador, Brazil
• Study site — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.