Insulin Resistance in Type I Diabetes in Pediatric Care

Withdrawn before enrolling

Conditions studied: Type 1 Diabetes

In brief

24 children (12 African-American, Hispanic, or American Indian, 12 Caucasian) previously diagnosed with type 1 diabetes mellitus will participate in this pilot study to evaluate the presence of hepatic and peripheral insulin resistance. The investigators will use this pilot information to test the hypothesis that insulin resistance occurs in some children with type 1 DM, is secondary to underlying risk factors, and is responsible for increased insulin needs. Methods will include a "step-up" hyperinsulinemic euglycemic clamp and infusion of the stable isotope 6,6-\[2H2\]-glucose. Patient and parent interviews will be conducted to gather information about nutritional intake, ethnicity, family history, and socioeconomic status. The investigators will also measure inflammatory cytokines and free fatty acids to determine whether they are associated with differences in insulin resistance among type 1 diabetes mellitus patients.

Key facts

Study ID

NCT00946426

Run by

Nationwide Children's Hospital

People needed

0

Starts

2009-07-01

Expected to finish

2010-05-01

Last updated by the study team

2015-05-15

Who can join

Age: 9 and older, up to 23. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Previously diagnosed with type 1 diabetes
• ages 9 -11 tanner 1 or 16-23 tanner 4-5

You may not qualify if…

• None

Where it is running

• Nationwide Children's Hospital — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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