Effects of Sulforaphane on Normal Prostate Tissue

Completed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Prostate Cancer

In brief

The investigators proposed to identify the biological effects of a high-sulforaphane broccoli sprout extract in normal prostate tissue. The investigators hypothesize that consumption of high-sulforaphane broccoli sprout extract every other day will inhibit growth of prostate cancer cells.

Key facts

Study ID

NCT00946309

Run by

Fred Hutchinson Cancer Center

People needed

45

Starts

2010-07-01

Expected to finish

2015-05-01

Last updated by the study team

2016-11-15

Who can join

Age: 40 and older, up to 75. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Men aged 40-75 years
• Low or intermediate grade prostate cancer (as defined by Gleason sum less than or equal to 7) and clinical stage T1 or T2
• Serum Prostate specific antigen less than 20 ng/ml
• Have elected radical prostatectomy, Brachytherapy or active surveillance as their primary treatment

You may not qualify if…

• No current physician diagnosed disease (including but not limited to): kidney disease requiring dialysis, cognitive deficits, substance abuse
• BMI < 18.5 kg/m2 or > 40 kg/m2
• Use of any hormonal treatments, including but not limited to testosterone
• Any previous cancer diagnosis or treatment within the previous five years, excluding non-melanoma skin cancer
• Inability or unwillingness to eat a diet that is free of Brassica vegetables for the duration of the study
• Use of any dietary supplements other than a multivitamin (including herbal preparations)
• Allergy to cruciferous vegetables or any of the specific fillers used in the placebo
• Usual consumption of > 5 servings per week of Brassica vegetables

Where it is running

• VA Puget Sound — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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