Scripps Polster Breast Care Center Investigational GeneBank

Completed

Conditions studied: Breast Cancer

In brief

Breast cancer is a disease of complex origin with a strong genetic component. The incidence of breast cancer is very high in monozygotic twins of patients, and it is thought that a high proportion and perhaps the majority of breast cancers arise in a small number of genetically susceptible women. Recent studies in human genetics have discovered several intervals in the human genome containing inherited variants that are statistically associated with the propensity to develop breast cancer. The investigators plan to use this knowledge to design a genetic screening test to guide recommendations for breast cancer screening with mammography. If the small group of genetically susceptible women can be identified, more effective breast cancer screening strategies can be implemented. In contrast, a very large proportion of women who undergo yearly mammography are at exceptionally low risk from a genetic perspective. Using genomic guidance could eventually reconfigure the most efficacious strategy to screen women for early detection of breast cancer. By developing a genetic screening panel based on genetic markers for breast cancer, the investigators will be able to more accurately determine a woman's individual risk for developing breast cancer.

Key facts

Study ID

NCT00945464

Run by

Scripps Translational Science Institute

People needed

1136

Starts

2008-07-01

Expected to finish

2015-06-01

Last updated by the study team

2015-10-16

Who can join

Age: 30 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age 30 years or older
• Be reliable, cooperative and willing to comply with all protocol-specified procedures
• Able to understand and grant informed consent
• Be undergoing screening or diagnostic breast imaging
• Have at least 5 years of breast imaging data available

You may not qualify if…

• Have a significant chronic medical condition which, in the Investigator's opinion, would interfere with the subject's participation in the study
• Have undergone treatment with any investigational agents or devices within thirty days preceding enrollment in the study
• Have taken any CNS sedation or depressants in past 12 hours

Where it is running

• Scripps Polster Breast Care Center — La Jolla, California, United States

Full record on ClinicalTrials.gov

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