Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable Bowel Syndrome
Completed · Not applicable · Has a placebo group
Conditions studied: Constipation-predominant Irritable Bowel Syndrome
In brief
In this study the investigators aim to compare the efficacy of neomycin to a combination of rifaximin and neomycin in the treatment of C-IBS subjects with methane on their breath test. This study will be conducted in collaboration with Dr. John DiBaise at the Mayo Clinic in Scottsdale, AZ and Dr. Satish Rao in Georgia Regents University in Augusta, GA.
Key facts
- Study ID
- NCT00945334
- Run by
- Mark Pimentel, MD
- People needed
- 37
- Starts
- 2009-08-01
- Expected to finish
- 2013-06-01
- Last updated by the study team
- 2015-08-10
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Rome III positive IBS subjects (18-75 years of age)
- Meet criteria for constipation predominant IBS symptoms including ≤ 3 complete spontaneous bowel movements per week with hard or lumpy stools.
- Presence of detectable methane on single breath sample (≥ 3ppm).
- If subjects are ≥ 50 years old, a colonoscopy had to have been completed within the past 5 years.
You may not qualify if…
- Subjects with history of intestinal surgery (except appendectomy or cholecystectomy)
- Recent antibiotic use (within the last 30 days)
- Subjects with known pelvic floor dysfunction
- Pregnancy
- Creatinine level > 1.4
- Poorly controlled/uncontrolled significant medical condition that would interfere with study procedures
- Subjects with hearing loss and/or tinnitus
- History of bowel obstruction
- History of celiac disease
- History of inflammatory bowel disease
- Cirrhosis
- Diabetes
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
- Georgia Health Sciences University — Augusta, Georgia, United States
Full record on ClinicalTrials.gov
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