Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)

Completed · Phase 3 · Has a placebo group

Conditions studied: Macular Edema Secondary to Central Retinal Vein Occlusion

In brief

This is a phase 3 study to determine the efficacy of VEGF Trap-Eye injected into the eye on vision function in subjects with macular edema as a consequence of central retinal vein occlusion.

Key facts

Study ID

NCT00943072

Run by

Regeneron Pharmaceuticals

People needed

189

Starts

2009-07-01

Expected to finish

2012-04-01

Last updated by the study team

2013-05-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects at least 18 years of age with center-involved macular edema secondary to CRVO with mean central retinal thickness ≥ 250 μm on OCT
• ETDRS best corrected visual acuity of 20/40 to 20/320 (73 to 24 letters) in the study eye

You may not qualify if…

• Previous treatment with anti-angiogenic drugs in the study eye (Pegaptanib sodium,anecortave acetate, bevacizumab, ranibizumab, etc.)
• Prior panretinal laser photocoagulation or macular laser photocoagulation in the study eye
• CRVO disease duration > 9 months from date of diagnosis
• Previous use of intraocular corticosteroids in the study eye or use of periocular corticosteroids in the study eye within the 3 months prior to Day 1
• Iris neovascularization, vitreous hemorrhage, traction retinal detachment, or preretinal fibrosis involving the macula in either the study eye or fellow eye

Where it is running

• Study site — Phoenix, Arizona, United States
• Study site — Tucson, Arizona, United States
• Study site — Arcadia, California, United States
• Study site — Beverly Hills, California, United States
• Study site — La Jolla, California, United States
• Study site — Mountain View, California, United States
• Study site — Oakland, California, United States
• Study site — Sacramento, California, United States
• Study site — Torrance, California, United States
• Study site — New London, Connecticut, United States
• Study site — Altamonte Springs, Florida, United States
• Study site — Fort Lauderdale, Florida, United States
• Study site — Fort Myers, Florida, United States
• Study site — Fort Myers, Florida, United States
• Study site — Miami, Florida, United States
• Study site — Palm Beach Gardens, Florida, United States
• Study site — Winter Haven, Florida, United States
• Study site — Augusta, Georgia, United States
• Study site — Chicago, Illinois, United States
• Study site — Wichita, Kansas, United States
• Study site — Baltimore, Maryland, United States
• Study site — Hagerstown, Maryland, United States
• Study site — Towson, Maryland, United States
• Study site — Boston, Massachusetts, United States
• Study site — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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