Measurement of Platelet Dense Granule Release in Healthy Volunteers

Withdrawn before enrolling · Not applicable

Conditions studied: Platelet Aggregation

In brief

Aspirin has been shown to reduce cardiovascular events in at risk individuals. Elucidation of mechanisms of aspirin resistance and a possible loss of effect of aspirin over time with chronic aspirin treatment necessitate a more precise method of measuring the "release phase" of platelet activation, including the release of dense granules from platelets.

Key facts

Study ID

NCT00942617

Run by

Vanderbilt University

People needed

0

Starts

2009-07-01

Expected to finish

2012-06-01

Last updated by the study team

2015-12-07

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Males over age 18
• Non-smokers
• No chronic medical illness
• No chronic medications

You may not qualify if…

• ASA/NSAID use previous 14 days.
• History of chronic NSAID use.
• Currently taking NSAIDs, opioid analgesics, corticosteroids, or anticoagulants.
• History of coronary artery disease, myocardial infarction, coronary artery bypass grafting, percutaneous angioplasty, diabetes mellitus or stroke.
• History of hypertension
• BMI >35
• Smokers
• History of gastric, duodenal, or esophageal ulcers or serious gastrointestinal bleed.
• History of frequent headaches, pain syndrome, or other condition requiring frequent use of analgesics.
• History of adverse reaction to ASA.
• Initial platelet count <100K/µl or >500K/µl.
• Initial hematocrit <35% or >50%.
• Weight less than 110 pounds.
• Female subjects will be excluded to avoid possible confounding uterine smooth muscle production of prostaglandins which various throughout the menstrual cycle.

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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