Comparison of Oral Dexamethasone Doses in Asthma Exacerbation

Completed · Not applicable

Conditions studied: Asthma, Reactive Airway Disease

In brief

Hypothesis: A 2-day course of oral dexamethasone is the superior option for the resolution of symptoms and prevention of relapse in the emergency department (ED) management of mild-moderate asthma exacerbations.

Key facts

Study ID

NCT00942201

Run by

Rady Children's Hospital, San Diego

People needed

125

Starts

2008-08-01

Expected to finish

2009-05-01

Last updated by the study team

2009-07-20

Who can join

Age: 2 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• children 2-17 years old
• with a history of wheezing (> 1 episode requiring ß-2 agonist therapy) who present to the ED with mild to moderate asthma exacerbations
• mild-moderate exacerbations are defined as a RSS < 11
• patients whose symptoms do not resolve after the first albuterol/atrovent treatment (given in the ED, or at home or via EMS within 1 hour prior to arrival to the ED) are eligible for enrollment

You may not qualify if…

• age < 2 years due to overlap with bronchiolitis
• use of steroids within 3 weeks
• recent exposure to TB, varicella, or herpes
• active varicella/herpes infections
• concomitant stridor, vomited 2 doses in ED
• severe asthma as defined by RSS > 12
• requirement for or pre-existing IV access
• need for immediate airway protection
• history of intubations for asthma or comorbidities (Chronic Lung Disease (CLD), Congenital Heart Defects (CHD), or neurologic disorders)

Where it is running

• Rady Children's Hospital — San Diego, California, United States

Full record on ClinicalTrials.gov

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