Dual Epidermal Growth Factor Receptor Inhibition With Erlotinib and Panitumumab With or Without Chemotherapy for Advanced Colorectal Cancer
Completed · Phase 2
Conditions studied: Colorectal Cancer
In brief
RATIONALE: Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Panitumumab may also stop the growth of colorectal cancer by blocking blood flow to the tumor. Drugs used in chemotherapy, such as irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether erlotinib hydrochloride given together with panitumumab is more effective with or without irinotecan in treating patients with metastatic colorectal cancer. PURPOSE: This randomized phase II trial is studying giving erlotinib hydrochloride together with panitumumab to see how well it works with or without irinotecan hydrochloride as second-line therapy in treating patients with metastatic colorectal cancer.
Key facts
- Study ID
- NCT00940316
- Run by
- Northwestern University
- People needed
- 28
- Starts
- 2010-01-18
- Expected to finish
- 2015-01-01
- Last updated by the study team
- 2019-05-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cancer Care & Hematology Specialists of Chicagoland — Arlington Heights, Illinois, United States
- Northwestern University, Northwestern Medical Faculty Foundation — Chicago, Illinois, United States
- Hematology/Oncology Associates — Chicago, Illinois, United States
- Joliet Oncology-Hematology Associates, Ltd. — Joliet, Illinois, United States
- Hope Cancer Center — Terre Haute, Indiana, United States
- Cancer Center of Kansas — Wichita, Kansas, United States
- Nebraska Methodist Hospital — Omaha, Nebraska, United States
- Virtua Memorial (Regional Cancer Care Associates of Mount Holly) — Mount Holly, New Jersey, United States
- Mercy Clinic Oncology and Hematology — Oklahoma City, Oklahoma, United States
- The Jones Clinic — Germantown, Tennessee, United States
Full record on ClinicalTrials.gov
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