A Study Of PF-04171327 In The Treatment Of The Signs And Symptoms Of Rheumatoid Arthritis
Completed · Phase 2 · Has a placebo group
Conditions studied: Rheumatoid Arthritis
In brief
This study will investigate the safety and efficacy of an investigational drug, PF-04171327 on the signs and symptoms of rheumatoid arthritis in patients that require glucocorticoids while on background methotrexate. This study will also look at the response of chemical and biological markers in rheumatoid arthritis patients. Lastly, this study will measure the PK (amount of drug in the blood) of methotrexate while patients may be taking PF-04171327.
Key facts
- Study ID
- NCT00938587
- Run by
- Pfizer
- People needed
- 86
- Starts
- 2009-10-07
- Expected to finish
- 2010-07-29
- Last updated by the study team
- 2023-11-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients ≥ 18 years of age, diagnosed with rheumatoid arthritis for a minimum duration of 3 months
- On stable dose of methotrexate for at least 6 weeks prior to screening
- Patient must have minimum disease activity level of ≥ 6 tender/painful joints, ≥ 6 swollen joints and CRP ≥ 0.7 mg/dL
- Not currently receiving steroid medication
You may not qualify if…
- Pregnant or nursing women
- Patients that have active infections, TB, HIV and/or Hepatitis B or C
- Patients that have a history of intolerance or significant adverse effects with the use of glucocorticoids
Where it is running
- Anniston Medical Clinic, PC — Anniston, Alabama, United States
- Pinnacle Research Group, LLC — Anniston, Alabama, United States
- Allergy, Asthma, Arthritis and Lung — Daytona Beach, Florida, United States
- Elite Research Institute — Miami, Florida, United States
- Millennium Research — Ormond Beach, Florida, United States
- Florida Medical Clinic, PA — Zephyrhills, Florida, United States
- The Arthritis Center — Springfield, Illinois, United States
- Premier Imaging Center — Bingham Farms, Michigan, United States
- Quest Research Institute — Bingham Farms, Michigan, United States
- Altoona Center for Clinical Research — Duncansville, Pennsylvania, United States
- MEDIPONT Plus, s.r.o. — České Budějovice, Czechia
- ARTMEDI UPD s r.o. — Hostivice, Czechia
- Revmatologicka ambulance — Prague, Czechia
- Fakultni Thomayerova nemocnice s poliklinikou — Prague, Czechia
- DC Mediscan — Praha 11 - Chodov, Czechia
- Centre for Assessment and Treatment of Rheumatic Diseases, Department of Medicine and Geriatrics — New Territories, Hong Kong
- Dr. Rethy Pal Korhaz es Rendelointezet\Reumatologia — Békéscsaba, Hungary
- Synexus Magyarorszag Kft. — Budapest, Hungary
- Debreceni Egyetem Orvos és Egeszsegtudomanyi Centrum — Debrecen, Hungary
- MAV Korhaz es Rendelointezet — Szolnok, Hungary
- Moscow SHI City Clinical Hospital #4, Department of Therapy of Moscow Faculty — Moscow, Russia
- Institution of Russian Academy of Medical Sciences Research Institute of Rheumatology RAMS — Moscow, Russia
- SI Saint-Petersburg SRI for Emergency Care named after I.I. Dzhanelidze — Saint Petersburg, Russia
- Regional State Institution of Healthcare Smolensk Regional Clinical Hospital — Smolensk, Russia
- Institute of Rheumatology — Belgrade, Serbia
Full record on ClinicalTrials.gov
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