Study to Determine Quicker Methods of Diagnosing Pneumonia Caused by a Breathing Machine in Critically Ill Patients

Completed

Conditions studied: Ventilator Acquired Pneumonia

In brief

Critically ill patients on a breathing machine are at risk of developing a type of pneumonia called Ventilator Acquired Pneumonia (VAP). The purpose of this study is to determine if regular lung rinses sent for microbiological testing can reduce the time to diagnose VAP. The study also plans to test the accuracy and speed of a new technology, using multiplexed automated digital microscopy, to identify the germs causing the VAP.

Key facts

Study ID

NCT00938002

Run by

Denver Health and Hospital Authority

People needed

37

Starts

2009-07-01

Expected to finish

2019-09-19

Last updated by the study team

2019-12-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written, informed consent (by surrogate if unconscious or if altered mental status)
• ≥ 18 years old
• Admission to a Medical Intensive care unit
• Orally/nasally intubated, evaluable within 72 h of initial intubation
• Expected to remain mechanically ventilated for at least 48 h after the first study procedure

You may not qualify if…

• Previously documented cystic fibrosis
• Diffuse bronchiectasis
• Severe or massive hemoptysis
• Presence of an advanced directive to withhold life-sustaining treatment
• Morbid state or expected to survive less than 14 days because of an advanced co-morbid medical condition
• Participation in a clinical trial of any unlicensed drug or device within 30 days
• Pregnant or Nursing

Where it is running

• Denver Health Medical Center — Denver, Colorado, United States

Full record on ClinicalTrials.gov

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