Treatment for Periodontal Disease in Dialysis Patients
Completed · Not applicable
Conditions studied: Periodontal Disease
In brief
The primary objective is to test the hypothesis that periodontal intervention in dialysis patients who have both periodontal disease and a historically high burden of cardiovascular disease will result in a reduction of inflammatory markers and improvement markers of nutrition health like albumin. Patients will be randomized to one of two treatment arms: intensive periodontal therapy or control-delayed periodontal therapy. Eligible patients will have 5 study visits over 7 to 12 months.
Key facts
- Study ID
- NCT00937976
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 60
- Starts
- 2008-08-01
- Expected to finish
- 2010-06-01
- Last updated by the study team
- 2012-05-07
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Presence of 12 or more teeth
- Presence of moderate to severe periodontal disease (2 or more teeth with at least 6 mm Clinical Attachment Loss and at least 1 site with Probing Depth > 5 mm)
- Receiving dialysis for at least 3 months
- English speaking
- Ability and willingness to give written informed consent for participation in the study
- Age 18 to 80 years
- Twelve or more teeth
You may not qualify if…
- Any severe co-morbid conditions likely to affect life expectancy within 1 year (for example, metastatic cancer)
- Any condition that would, in the judgement of the clinician, be a contraindication to dental treatment
- Dementia
- Pregnancy or lactation
- Inability to take oral medications
- Allergy or intolerance to minocycline, tetracyclines or polygycolate polymers
- Allergy to both penicillin and clindamycin
- Severe dental caries, pulpal or mucosal disease that would interfere with periodontal therapy
- Inability or unwillingness to follow the study protocol
Where it is running
- GO Health Center, School of Dentistry, University of North Carolina-Chapel Hill — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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