Adjunct Sedatives in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) Procedures
Completed · Phase 4
Conditions studied: Endoscopic Ultrasound (EUS), Endoscopic Retrograde Cholangiopancreatography (ERCP)
In brief
The purpose of this study is to compare meperidine/midazolam with diphenhydramine, meperidine/midazolam with promethazine, and meperidine/midazolam with placebo as sedation methods. The investigators are interested to see whether adjunct sedatives (diphenhydramine and promethazine) will improve sedation.
Key facts
- Study ID
- NCT00937924
- Run by
- University of California, Irvine
- People needed
- 304
- Starts
- 2008-02-01
- Expected to finish
- 2012-06-01
- Last updated by the study team
- 2024-02-26
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Willing participants between 18 and 75 years of age who present for ERCP or EUS at H.H. Comprehensive Chao Digestive Disease Center.
You may not qualify if…
- History of allergic or adverse reactions to midazolam, diphenhydramine, or promethazine.
- Acute asthma, narrow angle glaucoma, concurrent use of potent inhibitors of CYP3A4 (amprenavir, atazanavir, or ritonavir), pregnancy, or the inability to consent.
- Patients with conditions that preclude safe conscious sedation will be excluded.
Where it is running
- H.H. Chao Comprehensive Digestive Disease Center — Orange, California, United States
Full record on ClinicalTrials.gov
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