CCRC: Understanding the Effects of Omega-3 Fatty Acids Versus Lignans in Flaxseed on Metabolic and Inflammatory Markers Leading to Diabetes and Cardiovascular Disease
Completed · Not applicable
Conditions studied: Body Weight, Lipids, Blood Glucose, Insulin
In brief
The aim of this study is to compare the effects of flaxseed on atherogenic lipids, plasma inflammatory markers, and insulin sensitivity. We hypothesize that flaxseed omega-3 fatty acids will improve the lipid profile (decrease triglyceride, total and LDL-cholesterol and increase HDL-cholesterol). Flaxseed is the richest dietary source of lignan secoisolariciresinol diglucoside (SDG). Lignans are estrogens found in plant sources that behave similar to endogenous estrogens and have been associated with cardiovascular benefits due to their antioxidant activity. Therefore, we also hypothesize that flax-lignans will cause a significant decrease in LDL oxidation and in inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), IL-1B, serum fatty acid binding protein 4 (FABP-4), and serum amyloid attached to high density lipoprotein (HDL-SAA).
Key facts
- Study ID
- NCT00935922
- Run by
- University of California, Davis
- People needed
- 36
- Starts
- 2009-02-01
- Expected to finish
- 2010-04-01
- Last updated by the study team
- 2012-10-29
Who can join
Age: 40 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men or postmenopausal women in the 40-65 years age range. Body Mass Index in the range of 25-39
You may not qualify if…
- Women are are premenopausal
- Smoking
- Diabetes
- Cancer
- Gout
- Untreated thyroid disease
- Kidney Disease
- Liver Disease
- Use of lipid lowering drugs
- Use of insulin sensitizing drugs
- Use of ACE inhibitors or other blood pressure lowering medications
- Use of over the counter or prescription anti-obesity medications
- Weight loss of 10% or more within the last 12 months
Where it is running
- CCRC — Mather, California, United States
Full record on ClinicalTrials.gov
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