A Collaborative Model to Improve Blood Pressure (BP) Control and Minimize Racial Disparities

Completed · Phase 3

Conditions studied: Hypertension, Asthma

In brief

The purpose of the study is to determine the degree to which pharmacist-physician collaborative management (PPCM) of hypertension can be adopted and implemented in clinics with geographic and racial diversity and whether patients in clinics which implement PPCM achieve greater blood pressure control than patients in clinics which do not implement PPCM. Primary Hypothesis: BP control at 9 months will be significantly greater in patients from clinics randomized to the two PPCM BP intervention groups compared to the control group.

Key facts

Study ID

NCT00935077

Run by

University of Iowa

People needed

1441

Starts

2010-01-01

Expected to finish

2014-03-01

Last updated by the study team

2014-07-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English or Spanish speaking males or females, over 18 years of age with a diagnosis of hypertension,
• have uncontrolled BP defined as > 140 mm Hg SBP or > 90 mm Hg DBP for patients with uncomplicated hypertension; or > 130 mm Hg SBP or > 80 mm Hg DBP for patients with diabetes or chronic kidney disease, and
• receive care from one of the participating clinics.

You may not qualify if…

• current signs of hypertensive emergency (acute angina, stroke, or renal failure;
• severe HTN (systolic BP >200 or diastolic BP > 114 mm Hg);
• history of MI, stroke, or unstable angina in the prior 6 months;
• systolic dysfunction with a LV ejection fraction < 35% documented by echocardiography, nuclear medicine study, or ventriculography;
• renal insufficiency, defined by a glomerular filtration rate less than 20 ml/min or previously documented proteinuria > 1 gram per day;
• significant hepatic disease, including prior diagnoses of cirrhosis, Hepatitis B or C infection, or laboratory abnormalities (serum ALT or AST > 2 times control or total bilirubin > 1.5 mg/dl) in the prior 6 months;
• pregnancy;
• diagnoses of pulmonary hypertension or sleep apnea (unless treated by continuous positive pressure ventilation);
• poor prognosis with a life expectancy estimated less than 2 years;
• residence in a nursing home or diagnosis of dementia; and
• inability to give informed consent or impaired cognitive function (defined as > 3 errors on the 10-item Pfeiffer Portable Mental Status Questionnaire, administered during study intake).

Where it is running

• University of California San Diego — San Diego, California, United States
• St. Francis Hospital Medical Center — Hartford, Connecticut, United States
• University of Florida — Gainesville, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Idaho State University — Pocatello, Idaho, United States
• Midwestern University — Downers Grove, Illinois, United States
• Genesis Health System — Davenport, Iowa, United States
• Broadlawns Medical Center — Des Moines, Iowa, United States
• The University of Iowa — Iowa City, Iowa, United States
• Siouxland Medical Education Foundation — Sioux City, Iowa, United States
• Northeast Iowa Medical Education Foundation — Waterloo, Iowa, United States
• Cambridge Health Alliance — Cambridge, Massachusetts, United States
• SUNY-University of Buffalo — Buffalo, New York, United States
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Duke University — Durham, North Carolina, United States
• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
• Temple University — Philadelphia, Pennsylvania, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Spartanburg Regional Health Service District — Spartanburg, South Carolina, United States
• Texas Tech University Health Science Center — Amarillo, Texas, United States
• Seton Healthcare — Austin, Texas, United States
• University of Texas at El Paso — El Paso, Texas, United States
• Memorial Hermann Hospital System — Houston, Texas, United States
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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