A Phase 2 Study Of The 24-Hour Intraocular Pressure Lowering And Systemic Exposure Of PF-04217329

Completed · Phase 2 · Has a placebo group

Conditions studied: Glaucoma, Open-Angle, Ocular Hypertension

In brief

This study will characterize the effect of PF-04217329, alone and in combination with latanoprost, on circadian intraocular pressure and blood pressure in glaucoma patients. Blood samples will be collected to measure the amount of active metabolite of PF-04217329 in the plasma following dosing.

Key facts

Study ID

NCT00934089

Run by

Pfizer

People needed

31

Starts

2010-01-01

Expected to finish

2010-06-01

Last updated by the study team

2021-05-03

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of primary open-angle glaucoma or ocular hypertension in one or both eyes
• Intraocular Pressure (IOP) of at least 22 mmHg and not more than 30 mmHg in either eye at 8 AM after discontinuing previous glaucoma treatment
• Visual acuity correctable to 20/100 or better in each eye.

You may not qualify if…

• Closed/barely open anterior chamber angle or a history of acute angle closure in either eye.
• Diagnosis of a clinically significant or progressive retinal disease (eg, diabetic retinopathy, macular degeneration) in either eye.
• Advanced glaucoma or a history of severe central visual field loss in either eye.
• History of ocular surgery or trauma in either eye within 6 months of the screening visit.
• History of ocular infection, ocular inflammation, or laser surgery in either eye within 3 months of the screening visit.

Where it is running

• West Coast Clinical Trials, LLC — Cypress, California, United States
• Glory Medical Group — Garden Grove, California, United States
• East-West Eye Institute — Gardena, California, United States
• Ophthalmology Corporation — Long Beach, California, United States
• East-West Eye Institute — Los Angeles, California, United States
• Los Angeles Eye Medical Group — Los Angeles, California, United States
• Eye Research Foundation — Newport Beach, California, United States
• Southern California Glaucoma Consultants — Pasadena, California, United States

Full record on ClinicalTrials.gov

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