Functional Imaging of Tumor and Normal Tissue

Stopped early

Conditions studied: Head and Neck Cancer

In brief

Dynamic contrast-enhanced (DCE) - magnetic resonance imaging (MRI), diffusion-weighted (DW)-MRI, and fludeoxyglucose - positron emission tomography - computed tomography (FDG-PET-CT) are three modalities that generate non-invasive, functional images of tumors and normal tissues based on physiologic properties including perfusion, vascular permeability and glucose metabolism. Demonstrating that these parameters are associated with clinical outcome, either efficacy or toxicity, could enhance the ability to select patients for different treatment strategies and improve the therapeutic ratio.

Key facts

Study ID

NCT00933114

Run by

Duke University

People needed

21

Starts

2009-10-01

Expected to finish

2011-09-01

Last updated by the study team

2012-04-11

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically documented squamous cell carcinoma of the head and neck (AJCC stages II-IV, M0)
• Eligible anatomic sites: Oral cavity, oropharynx, hypopharynx, supraglottic and glottic larynx, or nasopharynx
• Curative intent concurrent chemoradiation
• Age > 18 years
• Karnofsky Performance Status > 60
• Able to undergo MRI with contrast (gadolinium) and/or FDG PET scan

You may not qualify if…

• Diabetes other than diet controlled
• MRI Absolute Contraindications including:
• Glomerular filtration rate < 60 ml/min
• Weight < 350 lb or current device limitations
• Metallic foreign bodies in the eye
• Cardiac pacemakers
• Clips in the central nervous system (ferromagnetic haemostatic)
• Automatic internal cardiac defibrillators
• Cochlear implants
• Shrapnel in vital locations
• Pregnant (positive pregnancy test) or lactating

Where it is running

• Duke University Medical Center, Department of Radiation Oncology — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.