A Phase I Study To Estimate The Effect Of Ketoconazole And Omeprazole On The Pharmacokinetics Of Dimebon In Healthy Subjects Who Are Normal Or Poor CYP2D6 Metabolizers
Completed · Phase 1
Conditions studied: Alzheimer's Disease, Huntington's Disease
In brief
This study will evaluate the potential for a drug-drug interaction of Dimebon with ketoconazole and omeprazole, potent inhibitors of the drug metabolizing enzymes CYP3A4 and CYP2C19, respectively.
Key facts
- Study ID
- NCT00931073
- Run by
- Pfizer
- People needed
- 24
- Starts
- 2009-07-01
- Expected to finish
- 2009-10-01
- Last updated by the study team
- 2009-11-18
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
- Subjects must have either a CYP2D6 EM (n=12) or PM (n=12) status based on genotyping at screening.
- Subjects must have a CYP2C19 EM status based on status at screening.
You may not qualify if…
- Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease.
- Subjects with any history of a previous seizure or convulsion or significant head trauma.
- Subjects specifically allergic to imidazole antifungal agents.
- Subjects specifically allergic to omeprazole or other proton pump inhibitors.
- Any condition possibly affecting drug absorption (eg, gastrectomy).
- Subjects with hypersensitivity reactions to Dimebon or other antihistamines.
- Consumption of grapefruit or grapefruit containing products within 7 days prior to the first dose of study medication.
- Subjects currently taking omeprazole, other proton pump inhibitors, antacids, H2-blockers or CYP2C19 inhibitors.
- Pregnant or nursing females; females of childbearing potential who are unwilling or unable to use an acceptable method of nonhormonal contraception as outlined in this protocol from at least 14 days prior to the first dose of study medication.
Where it is running
- Pfizer Investigational Site — Kalamazoo, Michigan, United States
Full record on ClinicalTrials.gov
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