Evaluation of Sodium Bicarbonate to Reduce the Incidence of Contrast Induced Chronic Kidney Injury in Patients With Kidney Disease
Stopped early · Phase 3
Conditions studied: Contrast Induced Kidney Injury.
In brief
Patients with Stage 3B, 4,or 5 Chronic Kidney Disease who are to undergo an angiography procedure with contrast agent will be asked if they are willing to join the trial. If so they will be screened and randomized to receive either sodium bicarbonate or saline before, during and after the contrast media is given. They will be asked for serum samples 1 to 3 days, 7, 30, 90 and 180 days after the procedure to evaluate whether the sodium bicarbonate has reduced the incidence of contrast induced chronic kidney disease by measuring their serum creatinine, as well as whether they have required renal dialysis or other renal replacement therapy.
Key facts
- Study ID
- NCT00930436
- Run by
- MD Scientific
- People needed
- 391
- Starts
- 2010-01-01
- Expected to finish
- 2012-09-01
- Last updated by the study team
- 2012-08-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Candidate for angiography
- Stage 3B, 4 or 5 Chronic kidney disease (i.e. eGFR <=44)
- Either sex over 18 years of age
You may not qualify if…
- Pregnant or breast feeding
- On any kidney replacement list
- Gastric tube in place or gastric drainage
- Uncorrected hypoglycemia
Where it is running
- Osceola Regional Medical Center — Kissimmee, Florida, United States
- Northside Hospital — St. Petersburg, Florida, United States
- Redmond Regional Medical Center — Rome, Georgia, United States
- St. Johns Hospital — Springfield, Illinois, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- St Luke's Health System — Kansas City, Missouri, United States
- Hackensack University Medical Center — Hackensack, New Jersey, United States
- Mt Sinai School of Medcine — New York, New York, United States
- Stony Brook University Medical Center — Stony Brook, New York, United States
- The Christ Hospital — Cincinnati, Ohio, United States
- St Luke's Heart and Vascular Center — Bethlehem, Pennsylvania, United States
- Geisinger Medical Center — Danville, Pennsylvania, United States
- Rhode Island Hospital — Providence, Rhode Island, United States
- The Miriam Hospital (Lifespan) — Providence, Rhode Island, United States
- Centennial Medical Center — Nashville, Tennessee, United States
- Baylor Heart and Vascular Hospital — Dallas, Texas, United States
- Fletcher Allen Hospital — Burlington, Vermont, United States
Full record on ClinicalTrials.gov
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