Effect of Diet Composition on Liver Fat and Glucose Metabolism
Completed · Not applicable
Conditions studied: Fatty Liver
In brief
This study is designed to determine if the amount of fat and saturated fat in the diet contributes to the development of a condition called fatty liver disease in the absence of changes in weight.
Key facts
- Study ID
- NCT00930371
- Run by
- University of Washington
- People needed
- 16
- Starts
- 2009-06-01
- Expected to finish
- 2012-09-01
- Last updated by the study team
- 2015-12-03
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-55 years old, men and women, otherwise in good general health, BMI >27 kg/m2
You may not qualify if…
- Abnormal glucose tolerance, fasting glucose>100 mg/dl or diabetes
- History of liver condition or alanine aminotransferase (ALT) above the upper limit of the normal range
- Use of medications that cause insulin resistance or fatty liver: niacin, glucocorticoids, estrogens, tamoxifen, amiodarone, accutane, sertraline, atypical antipsychotics, anti-HIV medications
- Chronic use of anti-inflammatory medications (aspirin, ibuprofen, naprosyn, steroids, etc)
- Average alcohol intake >20 grams/day
- Tobacco use
- Creatinine >1.5 mg/dl for men and >1.4 mg/dl for women
- Hematocrit <33%
- Pregnancy or lactation
- Significant weight loss within the past 6 months (>5% body weight)
- Claustrophobia or any contraindications to being placed in the magnet for the MRS scan such as pacemakers, defibrillators, brain aneurysm clips, etc.
- Other serious medical conditions or inflammatory conditions such as cancer, inflammatory arthritis, etc.
- History of multiple food allergies or intolerances or severe food allergies
- History of coronary artery disease, history of or treatment of hyperlipidemia, LDL >200 mg/dl, fasting triglycerides >300 mg/dl
- Weight >300 pounds
Where it is running
- University of Washington — Seattle, Washington, United States
- VA Puget Sound Health Care System — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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