Efficacy and Feasibility of a Personalized Treatment for Depression With Co-Occurring Anxiety

Completed · Not applicable

Conditions studied: Depression, Anxiety

In brief

This study will examine the feasibility and efficacy of a personalized psychotherapy treatment for people with depression and co-occurring anxiety.

Key facts

Study ID

NCT00930293

Run by

University of Pittsburgh

People needed

50

Starts

2009-07-01

Expected to finish

2012-06-01

Last updated by the study team

2016-02-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Currently in an episode of nonpsychotic major depression, as defined by the DSM-IV and documented by both the Structured Clinical Interview for Axis I, DSM-IV Disorders (SCID) and by a rating of greater than 15 on the 25-item Hamilton Rating Scale for Depression (HRSD)
• Panic spectrum risk category of at least 7, as defined by the Panic-Agoraphobic Spectrum Self-Report (PAS-SR), last month version
• Not currently receiving effective treatment
• Participants with suicidal ideation are eligible as long as outpatient treatment is deemed safe.

You may not qualify if…

• History of manic or hypomanic episode(s)
• History of schizophrenia or schizoaffective disorder
• Mood disorder due to a general medical condition or induced by substance use
• Presence of psychosis
• Current pregnancy or plans to become pregnant
• Current primary diagnosis of anorexia nervosa or bulimia nervosa (this does not include an eating disorder not otherwise specified [NOS])
• Current primary diagnosis of severe obsessive-compulsive disorder (OCD), as determined by clinician evaluation of symptom severity and temporal onset of symptoms
• Drug or alcohol abuse or dependence within the past 3 months (participants with episodic abuse related to mood episodes will not be excluded)
• Satisfies full DSM-IV criteria for antisocial personality disorder, as determined by SCID-II evaluation
• Requires inpatient treatment because of suicidal risk or psychotic symptoms (current suicidal thinking or parasuicidal behavior is not exclusionary if, in clinician judgment, it can be managed on an outpatient basis)
• Any of the following medical conditions:
• An index episode that is secondary to the effect of medically prescribed drugs, i.e., reserpine, antihistamines, etc.
• Presence of significant uncontrolled medical illness including cardiovascular disorder, kidney or liver disease, epilepsy, untreated hypertension, or unstabilized endocrine disease (stable medical conditions such as well-controlled diabetes or HIV positive status are not exclusionary provided the participant meets other inclusion and exclusion criteria)
• Current treatment with a pharmacologic, over-the-counter, or herbal therapy for depression or anxiety (unless the participant wishes to discontinue an ineffective treatment)
• History of poor or failed treatment response to an adequate dose and duration of citalopram

Where it is running

• Western Psychiatric Institute and Clinic — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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