Feasibility of Providing Cognitive Remediation to People With Schizophrenia in a Clinical Network

Completed · Phase 4

Conditions studied: Schizophrenia

In brief

This study will test whether a cognitive remediation program to treat people with schizophrenia can be successfully implemented in a network of research clinics.

Key facts

Study ID

NCT00930150

Run by

National Institute of Mental Health (NIMH)

People needed

52

Starts

2009-07-01

Expected to finish

2010-02-01

Last updated by the study team

2011-04-19

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Demonstrates adequate decisional capacity to make a choice about participating in the research study
• Diagnosis of schizophrenia or schizoaffective disorder, as defined by DSM-IV-TR criteria and confirmed by the Structured Clinical Interview for DSM-IV (SCID)
• Positive and Negative Syndrome Scale (PANSS) hallucinatory behavior, unusual thought content, and conceptual disorganization ratings of no greater than moderately severe (i.e., item scores must be less than or equal to 5)
• Meets all of the following cognitive performance and English language criteria:
• Learned English before age 12
• Able to complete the baseline Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) validly, based on the judgment of the investigator
• Raw score of 37 or greater on the Wide Range Achievement Test, reading subtest, 3rd edition (WRAT-3), used to establish minimum sixth grade reading level and estimated premorbid IQ
• Able to state specific goals relevant to the intervention that participant would like to achieve
• Able to participate in the computerized intervention, based on the judgment of the investigator

You may not qualify if…

• Psychiatric hospitalization within 8 weeks of random assignment
• Adjustment to antipsychotic treatment within 4 weeks of random assignment
• Currently taking an anticholinergic medication
• DSM-IV diagnosis of alcohol or substance abuse (other than nicotine) within the last month or a DSM-IV diagnosis of alcohol or substance dependence (other than nicotine) within the last 6 months
• History of mental retardation, pervasive developmental disorder, or other neurological disorder (such as a traumatic brain injury, epilepsy, or Parkinson 's disease)

Where it is running

• Yale University/Connecticut Mental Health Center — New Haven, Connecticut, United States
• Emory University — Atlanta, Georgia, United States
• Medical College of Georgia — Augusta, Georgia, United States
• University of Iowa Hospital — Iowa City, Iowa, United States
• University of Massachusetts — Worcester, Massachusetts, United States
• University of Minnesota School of Medicine — Minneapolis, Minnesota, United States
• The University of North Carolina — Chapel Hill, North Carolina, United States
• Philadelphia VA Medical Center-116A — Philadelphia, Pennsylvania, United States
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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