Safety Study of Cervical Sympathetic Block for Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage

Stopped early · Phase 2

Conditions studied: Vasospasm

In brief

To evaluate the feasibility of performing a cervical sympathetic block in patients with severe cerebral vasospasm involving the anterior cerebral circulation following aneurysmal SAH.

Key facts

Study ID

NCT00930072

Run by

University of Washington

People needed

7

Starts

2009-04-01

Expected to finish

2014-12-01

Last updated by the study team

2017-09-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• High grade spontaneous SAH (Fisher Grade III and IV)
• Secured aneurysm (clipped/coiled)
• Evidence of severe vasospasm - MCA mean flow velocity >200 cm/sec and Lindegaard ratio >6 OR Symptomatic vasospasm with either angiographic evidence (no angioplasty), or at least moderate severity according to TCD criteria (MCA mean flow velocity >150 cm/sec and Lindegaard ratio >3, or ACA vasospasm)
• Age ≥18

You may not qualify if…

• Allergy to local anesthetic or contrast
• Coagulation disorders with PT <70%, or INR >1.4, or PTT >1.5 times control and/or platelets <70,000x106/L
• Use of enoxaparin within 12 hours
• Use of clopidogrel within 7 days
• Use of coumadin within 5 days
• Use of ticlopidine within 14 days
• Use of intravenous thrombolytics within 10 days
• Any use of hirudin derivatives during ICU stay

Where it is running

• Harborview Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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