A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease

Completed · Phase 2 · Has a placebo group

Conditions studied: Alzheimer's Disease

In brief

The purpose of this study is to evaluate the effects of PF-04447943 compared to placebo on cognitive, behavioral and overall symptoms of Alzheimer's disease; evaluate the safety and tolerability of PF-0444793 compared to placebo; and determine the levels of PF-04447943 in the plasma over the course of the study.

Key facts

Study ID

NCT00930059

Run by

Pfizer

People needed

191

Starts

2009-09-10

Expected to finish

2010-09-22

Last updated by the study team

2020-11-19

Who can join

Age: 55 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Mild to moderate Alzheimer's disease (MMSE 14-26)
• Good general health (such controlled conditions as Type 2 diabetes and hypertension allowed)

You may not qualify if…

• Use of acetylcholinesterase inhibitors (donepezil, rivastigmine, or galantamine) or memantine within 12 weeks of the start of the study
• Significant cardiovascular disease in the past 6 months
• Illness other than Alzheimer's disease that could contribute to cognitive impairment
• History of stroke or seizure disorder

Where it is running

• Neurology Clinic, PC — Northport, Alabama, United States
• ATP Clinical Research, Inc. — Costa Mesa, California, United States
• Southwestern Research Incorporated — Glendale, California, United States
• Pacific Coast Imaging (for Imaging only) — Newport Beach, California, United States
• The Southwest Institute for Clinical Research, Inc. — Rancho Mirage, California, United States
• Pacific Research Network (Satellite Site) — San Diego, California, United States
• Pacific Research Network, Inc. (Satellite Site) — Vista, California, United States
• MD Clinical — Hallandale, Florida, United States
• Compass Research, LLC — Orlando, Florida, United States
• Berma Research Group — Plantation, Florida, United States
• Joliet Center for Clinical Research — Joliet, Illinois, United States
• Fort Wayne Neurological Center — Fort Wayne, Indiana, United States
• Agewell — Indianapolis, Indiana, United States
• Four Rivers Clinical Research, Inc. — Paducah, Kentucky, United States
• Advanced MRI — Lake Charles, Louisiana, United States
• Lake Charles Clinical Trials, LLC — Lake Charles, Louisiana, United States
• Neurocare, Inc. — Newton, Massachusetts, United States
• Neurobehavioral Research Inc — Cedarhurst, New York, United States
• Behavioral Medical Research of Staten Island — Staten Island, New York, United States
• University of Pittsburgh Alzheimer's Disease Research Center — Pittsburgh, Pennsylvania, United States
• Rhode Island Hospital, Alzheimer's Disease and Memory Disorders Center — Providence, Rhode Island, United States
• Neurology Clinic, PC — Cordova, Tennessee, United States
• Medical Arts Health Research Group — Kelowna, British Columbia, Canada
• Hamilton Health Sciences — Hamilton, Ontario, Canada
• Kawartha Regional Memory Clinic — Peterborough, Ontario, Canada

Full record on ClinicalTrials.gov

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