Cross-over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus

Completed · Not applicable

Conditions studied: Nystagmus

In brief

Involuntary oscillations of the eyes (nystagmus) impairs vision so that affected patients, who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV. Two medicines have been reported to suppress nystagmus and improve vision in such patients: gabapentin and memantine. The investigators set out to test which of these two drug was more effective by carrying out a double-blind cross-over study. In this way, we could determine which drug worked best in each patient.

Key facts

Study ID

NCT00928954

Run by

Case Western Reserve University

People needed

10

Starts

2005-02-01

Expected to finish

2009-05-01

Last updated by the study team

2016-07-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (18 years or older) males or females with acquired nystagmus that is degrading their vision

You may not qualify if…

• Pregnant women
• Individuals who cannot describe their visual symptoms, cooperate with testing, or give informed consent
• Individuals with intolerance of gabapentin or memantine

Where it is running

• Veterans Affairs Medical Center, 10701 East Boulevard — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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