Dose Ranging Study of ART621 in Subjects Diagnosed With Rheumatoid Arthritis Taking Methotrexate

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Rheumatoid Arthritis

In brief

The purpose of this clinical trial is to assess the safety, efficacy, tolerability, immunogenicity and pharmacokinetics of 3 dose levels of ART621 in the treatment of rheumatoid arthritis.

Key facts

Study ID

NCT00928317

Run by

Arana Therapeutics Ltd

People needed

13

Starts

2009-04-01

Expected to finish

2009-12-01

Last updated by the study team

2010-01-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provision of a valid written informed consent.
• Male or female subjects ≥ 18 and ≤ 80 years old.
• Women of childbearing potential, or men of fathering potential, must be using adequate (in the investigator's opinion) birth control measures (e.g. abstinence, oral contraceptives, intrauterine device, barrier method with spermicide, or surgical sterilisation) during the study. Female subjects of childbearing potential must test negative for pregnancy prior to enrolling in the study. Post menopausal (cessation of menses for more than 2 years) women are eligible for this study.
• Diagnosis of RA according to the revised (1987) American College of Rheumatology criteria for at least 6 months and no longer than 3 years prior to screening.
• Meet ACR functional class criteria I, II or III.
• Have active RA at the time of screening and at baseline, defined as ≥ 6 swollen joints and ≥ 6 tender joints (from 68 joint count) together with at least 2 of the following 3 criteria:
• CRP level ≥ 1.5 mg/dl;
• ESR by Westergren method ≥ 28 mm in the first hour; or
• morning stiffness ≥ 45 minutes.
• At least one of the following should be present at screening:
• documented history or current presence of positive rheumatoid factor;
• presence of serum anti-CCP antibodies; or
• screening radiographic erosion
• Have been tolerating concomitant methotrexate (oral or subcutaneous) for at least 3 months prior to screening and on a stable dose between 10-25 mg per week for at least 6 weeks prior to the first study dose. The route of administration must also be stable. Use of methotrexate dose of 25-50 mg every 2 weeks is also acceptable. (Other DMARDs taken concomitantly with methotrexate are not allowed. Those subjects concomitantly receiving additional DMARDs with methotrexate may enter the study by stopping the additional DMARD at least 4 weeks prior to first study dose).
• If using the following medication, the subject must be on a stable dose for the 4 weeks prior to the first study dose and maintain that dose throughout the study:
• oral corticosteroids, equivalent to ≤ 10 mg of prednisone/day.
• one nonsteroidal anti-inflammatory drug (NSAID).
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) or fibrates (see Section 7.1 for acceptable doses).
• Does not have active or latent TB according to eligibility assessment and screening rules (see Section 8.3.1).
• Is willing and able to comply with study visits and other protocol requirements.

You may not qualify if…

• Pregnant, nursing, or planning a pregnancy (both men and women) within 9 months of enrolment.
• Subjects weighing > 100 kgs.
• Screening laboratory tests:
• hemoglobin ≤ 8.0 gm/dl
• white blood cells ≤ 3.0 x103 cells/µl
• neutrophils ≤ 1.5 x 103 cells/µl
• platelets ≤100 x 103 cells/µl
• serum transaminase level (AST and ALT) ≥ 2 times upper limit of normal (ULN)
• serum creatinine ≥ 0.15 mmol/l
• Subjects with diagnosis of juvenile arthritis or other inflammatory or autoimmune diseases that might confound the evaluations of benefit from ART621 such as ankylosing spondylitis, systemic lupus erythematosus and Lyme disease.
• Subjects who have previously failed to respond to any oral or injectable anti-TNFα therapy or subjects who have had to stop anti-TNFα therapy for safety reasons. Subjects who have successfully responded to anti-TNFα therapy in the past (but discontinued for reasons other than safety or lack of efficacy) > 6 months prior to study day one may enrol. Patients who have participated in a previous anti-TNFα therapy study are eligible if they are confirmed to have received placebo.
• Subjects who have previously received the following anti-rheumatic drugs: interleukin-1 receptor antagonist [anakinra], rituximab, anti-CD4 antibody, abatacept, thalidomide, p38 MAP kinase inhibitor and other agents (other than those listed in Section 7.3).
• Subjects who have undergone plasmapheresis within 6 months prior to randomisation.
• Have received intraarticular, intramuscular, or intravenous corticosteroids, including intramuscular adrenocorticotropic hormone, during the 4 weeks prior to the first study dose, or non-stable doses of oral steroids.
• Subjects with a history of any clinically significant adverse reaction to murine or chimeric proteins, including serious allergic reactions.
• Subjects with Felty's syndrome or a history of Felty's syndrome.
• Subjects who have received or are expecting to receive any live virus or bacterial vaccinations within 1 month before first study dose, during the study, or up to 3 months after the study dose.
• Subjects with a history of, presence of, or at high risk of serious infection including:
• history of active TB, or positive Mantoux test or QuantiFERON Gold test or chest x-ray suggestive of active or healed TB or positive contact history with a subject with active TB within the past 3 months. If subjects have a positive Mantoux test but a negative QuantiFERON Gold test, they may be enrolled.
• a serious infection during the 3 months prior study entry (hospitalised or received IV antibiotics for an infection).
• chronic or recurrent infectious disease.
• systemic fungal infections
• opportunistic infection within 3 months prior to screening (refer to 1993 CDC Classification System for HIV Infection).
• subjects known, or suspected, to be infected with HIV, hepatitis B, or hepatitis C.
• subjects with planned joint replacement surgery or a history of infected joint prosthesis or who have received antibiotics for a suspected infection of a joint prosthesis if that prosthesis has not been removed or replaced.

Where it is running

• Tampa Medical Group P.A. — Tampa, Florida, United States
• Arthritis Center — Springfield, Illinois, United States
• Physician Research Collaboration, LLC — Lincoln, Nebraska, United States
• Westroads Medical Group — Omaha, Nebraska, United States
• Arthritis Northwest, PLLC — Spokane, Washington, United States
• Arthritis Clinic — Racine, Wisconsin, United States
• Instituto Medico Especializado IME — Buenos Aires, BUE, Argentina
• Instituto Medico CER — Quilmes, Bue, Argentina
• ILAIM-CEOM Inst. Latinoamericano de Inv. Medicas — Córdoba, CRD, Argentina
• Sanatorio Parque S.A. — Rosario, SFE, Argentina
• CAICI — Rosario, SFE, Argentina
• Ctro Polivalente de Asist e Invest Clinica CER — San Juan, SJN, Argentina
• Centro de Investigaciones Reumatológicas — San Miguel de Tucumán, TUC, Argentina
• Centro Medico Privado de Reumatologia — San Miguel de Tucumán, TUC, Argentina
• IMAI Research - Instituto Medico de Asistencia y Investigaci — Calle French, Argentina
• Centro Medico Privado de Reumatologia — San Miguel de Tucumán, Argentina
• Lyell McEwin Hospital — Elizabeth Vale, New South Wales, Australia
• Georgetown Arthritis Centre — Sydney, New South Wales, Australia
• Coast Joint Care — Maroochydore, Queensland, Australia
• The Queen Elizabeth Hospital — Woodville, South Australia, Australia
• Revmatologicka ambulance — Bruntál, Czechia
• Nemocnice Jihlava — Jihlava, Czechia
• ARTHROMED s. r. o. — Pardubice, Czechia
• Fakultni nemocnice Plzen — Plzen - Bory, Czechia
• Revmatologicky ustav — Prague, Czechia

Full record on ClinicalTrials.gov

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