Evaluating the Efficacy and Safety of Oral Ranirestat (40 and 80 mg) in Mild to Moderate Diabetic Sensorimotor Polyneuropathy
Completed · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Mild to Moderate Diabetic Sensorimotor Polyneuropathy
In brief
The purpose of this study is to determine the effect of 40 mg and 80 mg ranirestat on peroneal motor nerve conduction velocity relative to placebo in subjects with mild to moderate diabetic sensorimotor polyneuropathy.
Key facts
- Study ID
- NCT00927914
- Run by
- Eisai Inc.
- People needed
- 800
- Starts
- 2009-07-01
- Expected to finish
- 2013-02-01
- Last updated by the study team
- 2019-02-21
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects with Type 1 or Type 2, insulin-dependent or non insulin-dependent diabetes mellitus.
- Subjects with a history of distal symmetric polyneuropathy, secondary to diabetes, diagnosed in accordance with the American Academy of Neurology criteria.
- Female subjects, who are of non-reproductive potential (>=12 months post-menopausal or surgically sterile) or who are using adequate contraception which includes abstinence or double barrier methods (diaphragm and condom with spermicidal cream, intrauterine device and condom with spermicidal cream). Male subjects with partners of child-bearing potential must also use adequate contraception.
- Subjects must be able to read, understand, and provide written informed consent before enrolling in the study at screening.
You may not qualify if…
- History of diabetic foot ulcers or lower extremity amputation.
- Diabetic amyotrophy or non-diabetic cause of lower limb neuropathy/neuropathic symptoms.
- Clinically significant illness which, in the opinion of the investigator, would compromise a subject's suitability to participate in the study for reasons of safety or would confound the efficacy assessments.
Where it is running
- The Johns Hopkins Hospital — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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