Postoperative Pain and Functional Patient Outcomes After Functional Endoscopic Sinus Surgery

Completed · Phase 4 · Has a placebo group

Conditions studied: Pain, Postoperative

In brief

The aim of the study is to quantify postoperative pain after functional endoscopic sinus surgery (FESS) and investigate whether preemptive analgesia may positively impact intraoperative anesthetic management, decrease patient postoperative pain and discomfort, and improve patient functional outcomes.

Key facts

Study ID

NCT00927888

Run by

Stanford University

People needed

56

Starts

2007-08-01

Expected to finish

2010-08-01

Last updated by the study team

2016-05-19

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The study subjects will be 18-70 year old.
• The subjects will be American Society of Anesthesiology physical status I and II patients.
• Patients with chronic rhinosinusitis, presenting for bilateral functional endoscopic sinus surgery.
• The subjects should understand informed consent and study instructions, AND 5. The subjects should not participate in any other research protocols.

You may not qualify if…

• Patients with pre-existing chronic facial pain not related to chronic rhinosinusitis.
• Patients with pre-existing chronic pain of different etiology.
• Patients taking prescription pain medications.
• Patients taking antidepressant medications.
• Patients taking over-the-counter pain medications within 48 hours of scheduled surgery.
• Patients in whom oral opioid-containing analgesics would be contraindicated postoperatively.
• Patients with a known or suspected genetic susceptibility to malignant hyperthermia, or known sensitivity to Desflurane or other halogenated agents.
• Patients with the history of arrhythmias or significant coronary artery disease.
• Patients with psychological disorders.
• Patients who are unable to understand the questionnaires or the visual analogue scale (VAS) pain scores.
• Patients with the history of substance or alcohol abuse.
• Patients with compromised renal and liver function.
• Patients with abnormal coagulation status or platelet count less than 100,000.
• Pregnant patients.
• Patients with an allergy to Bupivacaine, Lidocaine or Epinephrine.
• Other patients that may be excluded by the investigator, based on medical history and physical examination

Where it is running

• Stanford University School of Medicine — Stanford, California, United States

Full record on ClinicalTrials.gov

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