Decreasing Dialysis Cardiovascular Risk: Daily Versus Longer Treatments

Status unconfirmed · Not applicable

Conditions studied: Cardiovascular Disease

In brief

Given the known increased risk of heart disease in hemodialysis patients, this study aims to evaluate the change in both size and function of the heart by using cardiac magnetic resonance imaging (MRI) in patients undergoing either daily long (4 hours, 6 times weekly), daily short (2 hours 6 times weekly), or alternate day conventional (4 hours, 3 times weekly) and alternate day long (8 hours, 3 times weekly) dialysis for 6 months from randomization. The patients are randomly put in the groups based on predetermined randomization schedule and the cardiologist trained in cardiac MRI readings is blinded to the patient treatment schedule. Given that changes in heart function may be seen with cardiac imaging techniques within 6 months, the expectation is that groups on daily treatment may have better outcome for this parameter as changes in volume and blood pressure may also be affected in a positive way in patients on daily dialysis.

Key facts

Study ID

NCT00925483

Run by

Dallas VA Medical Center

People needed

60

Starts

2004-08-01

Last updated by the study team

2010-02-25

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• End stage renal disease patients on hemodialysis

You may not qualify if…

• Weight > 350 lbs
• Known poor dialysis and or treatment compliance
• Unable to come for daily treatments if randomization occurs in this group
• Prognosis less than 6 months
• Difficulty in tolerating dialysis and possibility of discontinuation of dialysis before 6 months

Where it is running

• Dallas VA Medical Center — Dallas, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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