Breast Magnetic Resonance Imaging (MRI) Screening After Mantle Radiation Therapy

Stopped early

Conditions studied: Breast Cancer

In brief

Objectives: The objective of this single-arm, prospective study is to perform annual mammography and MRI breast cancer screening in women who underwent mantle-field irradiation between 1970-1995 at M. D. Anderson Cancer Center in order to compare the ability of MRI and standard mammography to identify breast cancer. In addition, we will determine whether the combination of breast MRI and mammography identifies smaller, earlier-stage tumors, which would lead to improved cure rates. We will also take the opportunity to determine the incidence and stage of breast cancer in this high-risk cohort.

Key facts

Study ID

NCT00925405

Run by

M.D. Anderson Cancer Center

People needed

10

Starts

2009-06-01

Expected to finish

2011-10-01

Last updated by the study team

2011-11-08

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients diagnosed with lymphoma prior to 1995
• The radiation therapy must have been delivered at M.D. Anderson from start to finish with complete records of dose received
• Patients must have received radiation therapy to the chest between the ages of 10 and 30

You may not qualify if…

• Patients with claustrophobia
• Obese patients (the equipment weight limit is 350 pounds and the maximum scanner bore diameter is 55 cm)
• Patients with myocardial infarction within 6 months of study entry
• Patients with unstable angina pectoris, uncontrolled congestive heart failure, or uncontrolled arrhythmias
• Patients with aneurysm clips, pacemakers, or other implanted devices that are not MRI compatible
• Pregnant patients
• Patients with compromised renal function, with a calculated glomerular filtration rate (cGFR) less than 60 ml/min/1.73m2.
• Patients who began their treatment outside of MD Anderson Cancer Center.

Where it is running

• UT MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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