A Study of Inhalation of 20,000 EU CCRE and Mucociliary Clearance (MCC) in Otherwise Healthy Individuals Who Are Current Cigarette Smokers

Completed · Phase 1

Conditions studied: Healthy, Cigarette Smoking

In brief

The purpose of this Phase 1 research study is to identify a dose of inhaled endotoxin that is safe (does not cause prolonged cough, shortness of breath or other problems), but causes changes in sputum cell samples that the scientists can measure. The investigators are also interested in seeing if the exposure to the endotoxin decreases the body's natural ability to clear mucus from the lungs.

Key facts

Study ID

NCT00924768

Run by

University of North Carolina, Chapel Hill

People needed

12

Starts

2009-05-01

Expected to finish

2012-06-01

Last updated by the study team

2013-08-06

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Must be current cigarette smokers
• Must be otherwise healthy
• Must be good sputum producers

You may not qualify if…

• Any acute illness any chronic illness which would impact results

Where it is running

• UNC Center for Environmental Medicine, Asthma and Lung Biology — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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