Xylitol Versus Saline in Chronic Sinusitis
Completed · Not applicable
Conditions studied: Chronic Sinusitis
In brief
Is a xylitol nasal rinse better or worse than saline on patient satisfaction.
Key facts
- Study ID
- NCT00924404
- Run by
- University of Iowa
- People needed
- 53
- Starts
- 2009-05-01
- Expected to finish
- 2014-08-01
- Last updated by the study team
- 2018-08-31
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 56 Adult subjects (18 or older) presenting to the ENT(ears, nose, throat) clinics who meet the diagnosis of chronic rhinosinusitis (CRS). Definition of CRS: Presence of at least 2 of the following 4 signs/symptoms for 12 weeks or longer despite medical management:
- Anterior and/or posterior mucopurulent drainage
- Nasal obstruction
- Facial pain, pressure, and/or fullness
- Decreased sense of smell
- In addition, objective evidence of sinus mucosal disease must be demonstrated on sinus CT imaging or direct endoscopic examination.
You may not qualify if…
- Cystic fibrosis
- Fungal sinusitis
- Immunocompromised status (use of long term oral steroids (> 30 days), AIDS, active malignancy or chemotherapy)
- Known Ciliary disorders
- Sinonasal tumors
- Pregnancy
- Group 2: CRS with antibody deficiency
- 56 Adult subjects (18 or older) presenting to the Allergy clinic who meet the diagnosis of chronic rhinosinusitis (CRS). Definition of CRS: Presence of at least 2 of the following 4 signs/symptoms for 12 weeks or longer despite medical management:
- Anterior and/or posterior mucopurulent drainage
- Nasal obstruction
- Facial pain, pressure, and/or fullness
- Decreased sense of smell
- In addition, objective evidence of sinus mucosal disease must be demonstrated on sinus CT imaging or direct endoscopic examination.
- Exclusion criteria:
- Cystic Fibrosis Sinonasal tumors Pregnancy
Where it is running
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
Full record on ClinicalTrials.gov
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