Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure

Status unconfirmed · Not applicable

Conditions studied: Heart Failure

In brief

The purpose of the study is to compare the effects of conivaptan and diuretics on renal blood flow and neurohormones.

Key facts

Study ID

NCT00924014

Run by

Hennepin County Medical Center, Minneapolis

People needed

8

Starts

2009-07-01

Expected to finish

2010-03-01

Last updated by the study team

2009-06-18

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a diagnosis of chronic congestive heart failure of any etiology
• Be between 18-80 years of age
• Able to provide consent
• Have a documented left ventricular ejection fraction within the last year of < 40%
• On a stable dose (no changes within 2 weeks) of 40 mg or greater daily dose of furosemide or its equivalent
• On standard HF therapy medications (ACEI or ARB and beta-blocker unless contraindicated)
• Have an estimated glomerular filtration rate (GFR) of 30 ml/minute or greater (based on the Cockcroft Gault calculation)
• Have a hemoglobin of > 10 grams/dl
• Have a negative urine pregnancy for women of childbearing years only

You may not qualify if…

• Acute coronary syndrome within 1 month
• Systolic blood pressure less than or equal to 90 mmHg at time of enrollment
• Poor peripheral venous access
• Severe concomitant disease which deemed by the investigator would render them unsuitable for this trial
• Allergy or contraindication to the use of iothalamate, PAH - Specifically any allergies to iodine or iodine containing products, history of asthma and hay fever which deemed by the investigator would render them unsuitable for this trial

Where it is running

• Hennepin county Medical Center — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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