Optimizing Local Anesthetic Concentration for Continuous Femoral Nerve Blocks
Completed · Phase 4
Conditions studied: Total Knee Arthroplasty, Knee Pain
In brief
This is a randomized, observer-masked, controlled study. Subjects will be patients undergoing bilateral total knee arthroplasty (TKA). One side (left or right) will be randomized to one of two treatment groups: a postoperative ropivacaine concentration of 0.1% or 0.4%. The contralateral side will receive the other possible ropivacaine concentration of 0.1% or 0.4%. The basal rate and patient-controlled bolus volume will depend upon the treatment group, but the total dose of local anesthetic is the same for each. For the duration of the study, all patients will receive the current usual and customary analgesics for bilateral TKA patients. All patients will receive a ropivacaine perineural infusions initiated in the operating room and continued until at least the afternoon of postoperative day (POD) 2, as well as oral acetaminophen, a sustained-release oral opioid; and celecoxib. Rescue opioid and route of administration will be determined by pain severity using a Numeric Rating Scale of 0-10, with 0 equal to no pain and 10 being the worst imaginable pain.
Key facts
- Study ID
- NCT00923598
- Run by
- University of California, San Diego
- People needed
- 48
- Starts
- 2009-06-01
- Expected to finish
- 2011-04-01
- Last updated by the study team
- 2019-12-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Primary, bilateral TKA
- Age 18 years or older
- Postoperative analgesic pain includes bilateral continuous femoral nerve blocks
You may not qualify if…
- Chronic, high-dose opioid use
- History of opioid abuse
- Any neuro-muscular deficit of either femoral nerves and/or quadriceps muscles
- Pregnancy
- Incarceration
Where it is running
- The Cleveland Clinic, Main Campus — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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