Breast Stem Cells in Women at Average Risk and Increased Risk for Breast Cancer
Completed
Conditions studied: Breast Cancer
In brief
Background: * Research suggests that breast cancers may arise from a population of stem cells in the normal mammary gland that produce clones of cancer cells. * Researchers are now trying to determine what events may initiate the formation of cancer cells. Objectives: * To look for and describe breast stem cells from normal breast tissue from women who do not have breast cancer. * To compare the breast stem cells between women at increased risk for breast cancer and women at average risk for breast cancer. * To show a relationship between the number and type of breast stem cells with the density (appearance) of the mammogram (breast x-ray). * To make cell cultures (grow cells under controlled conditions) from the breast stem cells. Eligibility: -Women 18 years of age and older who are at average or increased risk for breast cancer. Design: Participants complete a health history questionnaire, family history questionnaire and risk assessment questionnaire. * Participants have a mammogram and breast biopsy (surgical removal of a sample of breast tissue). * Women who can become pregnant have a urine pregnancy test....
Key facts
- Study ID
- NCT00923377
- Run by
- National Cancer Institute (NCI)
- People needed
- 3
- Starts
- 2007-03-23
- Expected to finish
- 2010-05-11
- Last updated by the study team
- 2017-07-02
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may not qualify if…
- Current use of hormonal therapies (e.g. tamoxifen, aromatase inhibitors, hormone replacement therapy, oral contraceptive pills, topical or vaginal hormone medications are allowed.)
- Chemotherapy and radiation within 3 months prior to breast biopsy procedure.
- Breastfeeding within 3 months.
- Pregnancy (determined by urine dipstick).
- A suspicious unbiopsied lesion by physical examination or mammography of the breast(s) which is being studied.
- Bleeding disorder.
- Warfarin, low molecular weight heparin, or heparin use.
- History of bilateral breast radiation.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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