Longitudinal Study in Perimenopausal Women With Risk Factors for Atherosclerosis

Completed

Conditions studied: Atherosclerosis

In brief

The study hypothesis (or theory) is that monthly loss of iron before menopause may reduce women's risk of hardening of the arteries, or atherosclerosis. This study uses noninvasive, noncontrast magnetic resonance imaging (MRI) of arteries in women entering menopause. This will help to determine if there is a correlation between iron accumulation and hardening of the arteries. In addition, blood levels of hormones will be measured to help show differences due to hormone levels vs. iron accumulation.

Key facts

Study ID

NCT00921011

Run by

Ohio State University

People needed

177

Starts

2009-05-01

Expected to finish

2018-03-01

Last updated by the study team

2018-04-05

Who can join

Age: 40 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• women at least 40 yrs of age
• between 1 and 6 menstrual cycles in the past 12 months
• 2 or more of the following risk factors: high blood pressure, diabetes, high cholesterol, smoking
• no known heart or vascular disease

You may not qualify if…

• any known cardiovascular disease such as coronary disease, peripheral vascular disease, heart failure
• contraindication to MRI scan (e.g. aneurysm clip, iron-containing metal)
• NOTE that orthopedic hardware is usually MRI-compatible. We will go over detailed screening before enrollment.

Where it is running

• The Ohio State Univeristy Medical Center — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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