Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART)

Completed · Phase 3 · Has a placebo group

Conditions studied: Asthma

In brief

Vitamin D supplementation given to pregnant women will prevent asthma in their offspring and children.

Key facts

Study ID

NCT00920621

Run by

Brigham and Women's Hospital

People needed

876

Starts

2009-09-01

Expected to finish

2023-08-01

Last updated by the study team

2026-05-12

Who can join

Age: 18 and older, up to 39. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Personal history of asthma, eczema, allergic rhinitis or a history of asthma, eczema, allergic rhinitis in the biological father of the child
• Gestational age between 10 and 18 weeks at the time of randomization
• Maternal age between 18 and 39 years
• Not a current smoker
• English or Spanish speaking
• Intent to participate for the full 4 years (through Pregnancy and then until the 3rd birthday of the child)

You may not qualify if…

• Not meeting inclusion criteria
• Gestational age greater than 18 weeks
• Presence of chronic medical conditions
• Taking vitamin D supplements containing more than 2000 IU/day of vitamin D3
• Multiple gestation pregnancy (twins, triplets)
• Pregnancy achieved by assisted reproduction techniques (e.g., IUI, IVF)

Where it is running

• Robert Zeiger, MD — San Diego, California, United States
• George O'Connor, MD — Boston, Massachusetts, United States
• Leonard Bacharier, MD — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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