Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis
Completed · Phase 4
Conditions studied: Interstitial Cystitis
In brief
Anecdotal evidence suggests female patients with painful bladder disorder interstitial cystitis (IC) can experience a significant attenuation of their systems while breastfeeding. Since it has been shown that postpartum lactation is a time associated with decreased levels of stress, and stress has been shown to exacerbate IC-related pain, the investigators have developed an interest in the effects of the hormones involved in postpartum lactation on stress and pain. Based on a series of pre-clinical experiments, the investigators believe the hormone oxytoxin has both analgesic and anxiolytic properties which make it a potentially useful agent for the treatment of stress-exacerbated chronic pain syndrome such as IC. Therefore, the investigators propose a double-blinded, placebo-controlled crossover trial of intranasal oxytocin vs. intranasal saline for bladder pain in a cohort of patients with IC and some degree of continuous, daily pain.
Key facts
- Study ID
- NCT00919802
- Run by
- University of Alabama at Birmingham
- People needed
- 25
- Starts
- 2010-06-01
- Expected to finish
- 2015-09-01
- Last updated by the study team
- 2017-05-23
Who can join
Age: 19 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 19 - 65 years of age
- Must meet the current National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) diagnostic criteria for interstitial cystitis and have some degree of continuous daily pain
You may not qualify if…
- Pregnancy
- Under the age of 19
- Older that the age of 65
- Breastfeeding women
- Uncontrolled hypertension
- History of significant cardiac or pulmonary disease (including arrhythmias)
- Known allergy to oxytocin
- Severe psychiatric disease
- Patients who have undergone procedural interventions within the past month related to their interstitial cystitis
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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