Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis
Withdrawn before enrolling
Conditions studied: ABO Incompatibility, Hemolytic Disease of Newborn, Neonatal Jaundice, Neonatal Hyperbilirubinemia
In brief
The purpose of this research study is to more accurately measure the amount of true red blood cell breakdown (hemolysis) in newborn babies with potentially problematic blood type mismatch with their mothers (ABO incompatibility), and to examine how the true level of red blood cell destruction relates to other laboratory tests obtained in newborns with jaundice. A better understanding of the true amount of red blood cell destruction that is caused by blood type mismatch, as well as how it relates with other laboratory tests ordered for ABO incompatibility and red blood cell destruction, would help avoid unnecessary testing, treatment and prolonged hospital stays in such babies.
Key facts
- Study ID
- NCT00917007
- Run by
- State University of New York - Upstate Medical University
- People needed
- 0
- Starts
- 2009-06-01
- Expected to finish
- 2010-11-01
- Last updated by the study team
- 2021-10-25
Who can join
Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- written informed consent
- mother blood type O
- mother Rh +
- healthy infants
- ≥37 wks gestation
- ≥ 2500 gm birth weight
- Apgar ≥5 at 1 and 5 minutes
You may not qualify if…
- major anomalies
- infants evaluated for sepsis or infants with transitional respiratory problems requiring >6 hrs observation in the NICU
- significant birth trauma with continued bruising and/or sequestration of blood still evident at the time of discharge
- known perinatal blood loss with hemodynamic consequences such as persistent tachycardia, need for fluid boluses or supplemental oxygen
- neonatal anemia with Hb<13.5g/dL
- known family history of hereditary hemolytic disease such as G6PD deficiency, hereditary spherocytosis or hereditary elliptocytosis
Where it is running
- Crouse Hospital — Syracuse, New York, United States
- SUNY Upstate Medical University — Syracuse, New York, United States
Full record on ClinicalTrials.gov
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