Study Evaluating The Long-Term Safety And Efficacy Of Subcutaneous Bapineuzumab

Stopped early · Phase 2

Conditions studied: Alzheimer Disease

In brief

This study will evaluate the safety and tolerability of bapineuzumab when administered by subcutaneous injection. The study is open only to subjects who participated in the preceding double-blind study (3133L1-2203 US). Subjects will receive weekly injections of bapineuzumab for 3 years (156 doses). One dosage level will be included: 5 mg/week. All subjects will receive active treatment (bapineuzumab) and no subjects will receive placebo.

Key facts

Study ID

NCT00916617

Run by

Pfizer

People needed

62

Starts

2009-06-01

Expected to finish

2012-09-01

Last updated by the study team

2017-06-01

Who can join

Age: 50 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of probable Alzheimer disease
• Completed preceding double-blind study (3133L1-2203 US)
• MMSE score > 9.

You may not qualify if…

• Significant brain MRI abnormalities
• Clinically important psychiatric symptoms
• History of stroke

Where it is running

• Banner Alzheimer's Institute — Phoenix, Arizona, United States
• Pharmacology Research Institute — Encino, California, United States
• Brain Matters Research — Delray Beach, Florida, United States
• MD Clinical — Hallandale, Florida, United States
• Palm Beach Neurology - Premiere Research Institute — West Palm Beach, Florida, United States
• Neurostudies.net — Decatur, Georgia, United States
• Dekalb Neurology Associates, LLC — Lawrenceville, Georgia, United States
• NeuroStudies.net — Lawrenceville, Georgia, United States
• Clinical Research Institute — Wichita, Kansas, United States
• Monroe Community Hospital — Rochester, New York, United States
• Rhode Island Mood and Memory Research Institute — East Providence, Rhode Island, United States
• Butler Hospital — Providence, Rhode Island, United States
• Texas Neurology, P.A. — Dallas, Texas, United States
• The Memory Clinic — Bennington, Vermont, United States
• University of Wisconsin, Department of Surgery — Madison, Wisconsin, United States
• University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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