Biomarkers for Pain in Spinal Cord Injury Patients

Completed

Conditions studied: Traumatic Spinal Cord Injury, Neuropathic Pain

In brief

The investigators propose to compare plasma protein profiles for SCI patients with/without chronic neuropathic pain in order identify biomarker(s) that are associated with this medical condition. Secondly, the investigators propose to identify a temporal relationship to initial SCI at which these biomarkers manifest. Our working hypothesis is that sustained alterations in specific inflammatory molecules are associated with chronic neuropathic pain following SCI, and that their plasma levels can serve as biomarkers to identify patients at risk for the development of neuropathic pain. Additionally the investigators are collecting skin tissue biopsy samples from patients following acute and chronic spinal cord injury to create vector-free human iPS cells from fibroblasts by direct delivery of reprogramming proteins.

Key facts

Study ID
NCT00913471
Run by
The University of Texas Health Science Center, Houston
People needed
120
Starts
2009-06-01
Expected to finish
2026-06-01
Last updated by the study team
2026-06-16

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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