Production of Free Fatty Acids From Blood Triglycerides

Completed

Conditions studied: Diabetes Mellitus, Type 2, Insulin Resistance, Dyslipidemias

In brief

The overall hypothesis of these studies is that circulating triglycerides, coming primarily from fat in the diet, are an important source of free fatty acids. Free fatty acids are the major fat fuel in the body, and when they are elevated in the blood they are thought to raise the risk of cardiovascular disease by causing insulin resistance (in some cases leading to diabetes), raising blood pressure, and other effects. The investigator will use sophisticated methods for tracing triglycerides and free fatty acids in the blood. These methods involve the administration of low doses of radioactive and stable isotopes of naturally occurring fats. The studies will determine the contribution of triglycerides to free fatty acids in normal people and also in people with diabetes.

Key facts

Study ID

NCT00911482

Run by

Mayo Clinic

People needed

16

Starts

2008-06-01

Expected to finish

2012-01-01

Last updated by the study team

2012-11-07

Who can join

Age: 35 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Type 2 diabetes
• Atherogenic dyslipidemia
• Obesity

You may not qualify if…

• Kidney disease
• Liver disease
• Coronary artery disease
• Retinopathy
• Neuropathy

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.