Weight Loss in Pre-Hypertensive Patients With Diastolic Dysfunction

Stopped early · Not applicable

Conditions studied: Obesity, Heart Disease, Weight Loss, Diastolic Dysfunction

In brief

The focus of this study is to observe the impact of weight loss in overweight individuals who have pre-hypertension (have a blood pressure reading of 121-139/81-89 mm Hg). The specific focus is to observe the difference in diastolic dysfunction (heart function) in these individuals at the beginning of the study and then again after 24-28 weeks. Diastolic dysfunction in this population indicates an increased risk of heart failure in the future. The aim of this study is to prevent or reduce the risk of heart failure in overweight individuals with pre-hypertension.

Key facts

Study ID

NCT00911209

Run by

Ragavendra Baliga

People needed

1

Starts

2008-07-01

Expected to finish

2010-12-01

Last updated by the study team

2012-10-15

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults age ≥ 21 years
• BMI ≥30
• Individuals with diagnosis pre-hypertension at the time of screening, defined as either a blood pressure measurement of 130-139/85-89 mm Hg
• Echocardiographic EF >50%
• Echocardiographic evidence of diastolic dysfunction;

You may not qualify if…

• Patients receiving antihypertensive medications
• Patients receiving diabetic medication

Where it is running

• The Ohio State University Medical Center — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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