Optical Tomography With Ultrasound Guidance
Completed
Conditions studied: Breast Cancer
In brief
The investigators propose to validate the utility of their novel hybrid imaging technique for accurate diagnosis of breast lesions, and for assessing chemotherapy response of cancer treatment and predicting treatment efficacy. The investigators' unique hybrid technique is implemented by simultaneously deploying near infrared (NIR) optical sensors and a commercial ultrasound (US) transducer mounted on a hand-held probe, and utilizing co-registered lesion structure information provided by ultrasound to improve the optical tomography. As a result, the optical tomography assisted with US has overcome problems associated with intense light scattering and has provided reliable tumor angiogenesis distributions. Initial results with a small group of patients who underwent biopsy have shown that early stage invasive cancers present two-fold greater total hemoglobin concentration on average than fibroadenomas and other benign lesions. Initial results of advanced cancers have shown that the angiogenesis distribution is highly distorted and heterogeneous, and the distorted distributions correlate with histological microvessel density counts and can be used to assess chemotherapy response. The objective of this study is to validate the investigators' initial results that NIR light guided by ultrasound can improve breast cancer diagnosis and monitor chemotherapy response.
Key facts
- Study ID
- NCT00908609
- Run by
- UConn Health
- People needed
- 340
- Starts
- 2007-04-01
- Expected to finish
- 2012-01-01
- Last updated by the study team
- 2017-04-17
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women undergoing ultrasound guided biopsy or breast cancer patients undergoing neoadjuvant thermotherapy treatment
You may not qualify if…
- Women under 18 years old.
Where it is running
- University of Connecticut Health Center — Farmington, Connecticut, United States
- Hartford Hospital — Hartford, Connecticut, United States
Full record on ClinicalTrials.gov
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