Early Immune Responses to Vaccination - A Substudy to HVTN 205

Completed

Conditions studied: HIV Infections

In brief

HVTN 908 is a sub study of the HIV vaccine trial, HVTN 205. The purpose of this sub study is to better understand how a person's immune system responds to vaccines, particularly HIV vaccines. More specifically, researchers will determine whether early responses in the immune system help predict strong and long-lasting immunity.

Key facts

Study ID

NCT00908323

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

47

Starts

2009-07-01

Expected to finish

2012-07-01

Last updated by the study team

2021-10-15

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Scheduled receipt of a vaccine or placebo in HVTN 205
• For participants in Part B of HVTN 205, enrollment in HVTN 908 and HVTN 205 at the same time
• HVTN 908 assessment of understanding: completion of a questionnaire prior to enrollment; demonstration of understanding for all questionnaire items answered incorrectly.
• Body weight of 50 kg (110 lbs) or more
• Hemoglobin of 12.0 g/dL or more for female volunteers, and 13.0 g/dL or more for male volunteers
• Negative HIV-1 and -2 blood test

You may not qualify if…

• Clinically significant medical condition, physical examination finding, clinically significant abnormal laboratory results, or past medical history with clinically significant implications for current health. More information on this criterion can be found in the study protocol.
• Any medical, psychiatric, or occupational, or other condition that, in the judgment of the investigator, would interfere with, or serve as a contraindication to, protocol adherence, or a participant's ability to give informed consent
• Pregnancy

Where it is running

• Alabama Vaccine CRS — Birmingham, Alabama, United States
• Bridge HIV CRS — San Francisco, California, United States
• Seattle Vaccine and Prevention CRS — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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