Self-guided Depression Treatment on Long-duration Spaceflights: A Continuation Study

Completed · Not applicable

Conditions studied: Depression

In brief

Use of a computer-based treatment will reduce level of depression.

Key facts

Study ID

NCT00906581

Run by

Beth Israel Deaconess Medical Center

People needed

68

Starts

2009-04-01

Expected to finish

2009-09-01

Last updated by the study team

2017-04-13

Who can join

Age: 30 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Criteria for matching to astronaut corps population:
• Completed 4 or more years of college or university education
• Age 30-60
• Has access to a personal computer and regularly uses it (at least twice per week)
• Clinical criteria:
• Score of 10 or higher on Hamilton Depression Inventory (which yields equivalent scores to the Hamilton Depression Rating Scale).
• Has a diagnosis of minor depression consisting of 2 to 4 DSM-IV symptoms of depression, one of which is depressed mood or anhedonia
• Presence of depressive symptoms for at least 2 weeks but less than 2 years
• Patient willing to avoid or postpone the use of antidepressant drugs during the treatment portion of the study (6 weeks)

You may not qualify if…

• Presence of more severe depression or dysthymia within the past 6 months (to rule out persons currently remitting from major depression)
• Current or past diagnosis of organic mental disorder, schizophrenia, bipolar disorder, or current psychotic symptoms
• Current suicidal ideation or any history of suicide attempt or self-injurious behavior
• Presence of comorbid antisocial personality disorder
• Any current substance abuse/dependence (other than nicotine or caffeine)
• Suicidal ideation or parasuicidality
• Current homicidal ideation
• Recent regimen changes within the past 2 months in prescribed antidepressants, benzodiazepines, or buspirone
• Currently receiving psychotherapy or mental health counseling
• Exposure to PST in previous studies
• Moderate or sever cognitive impairment (Mini Mental State Score <= 23)
• Near terminal medical illness (physician estimates < 6 months to live)

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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