Computed Tomography (CT) Perfusion Imaging of Lung Cancer

Stopped early · Not applicable

Conditions studied: Carcinoma, Non Small Cell Lung

In brief

This is an experimental study of the feasibility and efficacy of CT perfusion (CTP) imaging (CT blood flow measurements) in subjects with non-small cell lung cancer.

Key facts

Study ID

NCT00905801

Run by

University of Pittsburgh

People needed

16

Starts

2009-06-01

Expected to finish

2014-09-01

Last updated by the study team

2015-10-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient with any stage non-small cell lung cancer (NSCLC) who will undergo imaging with CT of the chest with intravenous contrast as standard of care. Other imaging tests will be performed as clinically indicated.
• Patient should be receiving, or planning to receive, or have received systemic therapy (chemotherapy and/or novel agents) treatment with or without radiotherapy. Patients should not be receiving adjuvant or postoperative treatment but neoadjuvant treatment is allowed.
• Histologically or cytologically proven NSCLC.
• At least one measurable primary or other intrathoracic/supraclavicular lesion ≥ 1 cm, according to Response Evaluation Criteria in Solid Tumors (RECIST); this lesion should be either proven to be malignant by biopsy or be considered malignant based on its evolution on previous imaging studies. A scan within 3-6 months prior to registration can be used as the baseline scan.
• Age 18 years or older and ability to provide informed consent.
• Subjects must use medically appropriate contraception if sexually active; women of childbearing potential must not be pregnant or breastfeeding
• Subjects must have normal renal function to participate. Standard laboratory testing to evaluate renal function will be performed prior to administering IV contrast and will be available as standard of care. Renal impairment is defined as a glomerular filtration rate of less than 60 ml/min/1.73 m2 BSA, derived from the patients' serum creatinine concentration.

You may not qualify if…

• Subjects of reproductive potential, who are sexually active but unwilling and/or unable to use medically appropriate contraception, or women who are pregnant or breastfeeding;
• Established allergy to iodine containing contrast media

Where it is running

• Hillman Cancer Center: University of Pittsburgh Cancer Institute / UPMC Department of Radiology — Pittsburgh, Pennsylvania, United States
• University of Pittsburgh Cancer Institute - Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
• University of Pittsburgh Cancer Institute — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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