Cancer Risk in Organ Transplant Recipients and End-Stage Renal Disease

Completed

Conditions studied: Immunocompromised Host, Organ Transplantation, Cancer

In brief

Background: * Solid organ transplantation provides life-saving treatment for end-stage organ disease but is associated with an increased cancer risk because of the need for long-term immunosuppression * End-stage renal disease (ESRD), the most common type of end-stage organ disease leading to transplant, is itself linked to increased risk for some cancers * The role of immunosuppression and other factors causing cancer in this setting are not fully understood. Objectives: * To characterize cancer risk in transplant recipients and identify risk factors. * To characterize risk for transmission of cancer from organ donors to recipients. * To describe cancer risk in ESRD. Eligibility: Patients are not required for this study. Data are gathered from existing databases of ESRD patients, organ transplant patients and cancer registries. Design: * Databases of 1) U.S. transplant recipients, donors and wait list candidates and 2) U.S. ESRD patients will be linked to multiple U.S. cancer registries to identify cancers in transplant recipients and ESRD patients. * The spectrum of cancer risk in transplant recipients and ESRD patients will be evaluated in detail. * The cancer risk in transplant recipients will be examined in relation to whether the donors had cancer. * The proposed cancer risk factors (e.g., underlying medical condition, infection with cancer-causing viruses, immunosuppressive medications) documented in transplant and ESRD files will be studied for association with increased risk of particular types of cancer.

Key facts

Study ID

NCT00904579

Run by

National Cancer Institute (NCI)

People needed

19929901

Starts

2006-07-01

Expected to finish

2020-04-22

Last updated by the study team

2020-04-28

Who can join

Age: any, up to 100. Sex: any. Healthy volunteers: not accepted.

Where it is running

• California Cancer Registry — Sacramento, California, United States
• Colorado Cancer Registry — Denver, Colorado, United States
• Connecticut Cancer Registry — Hartford, Connecticut, United States
• Georgia Cancer Registry — Atlanta, Georgia, United States
• Iowa Cancer Registry — Iowa City, Iowa, United States
• National Cancer Institute (NCI), 9000 Rockville Pike — Bethesda, Maryland, United States
• New Jersey Cancer Registry — New Brunswick, New Jersey, United States
• New York Cancer Registry — Albany, New York, United States
• Seattle Cancer Registry — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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